Photocatalytic Pyridine Synthesis with Enaminones and TMEDA under Metal-Free Conditions
Junlong Zeng, Tao Zhou, Jianchao Liu, Jie‐Ping Wan
Abstract
Reported herein is a new photocatalytic annulation for the synthesis of 2,3,4,6-tetrasubstituted pyridines with enaminones and N,N,N′,N ′-tetramethyl ethylenediamine (TMEDA). The photocatalytic reactions take place without requiring a transition metal reagent and provide products with broad scope. The methyl in TMEDA acts as the carbon source in pyridine ring construction, and BrCF 2 CO 2 Et plays the role of the terminal oxidant for free radical quenching.
Topics & Concepts
PhotocatalysisPyridineMetalChemistryPhotochemistryCombinatorial chemistryOrganic chemistryCatalysisCatalytic C–H Functionalization MethodsFluorine in Organic ChemistryAsymmetric Hydrogenation and Catalysis