Regioselectively switchable alkyne cyclotrimerization catalyzed by a Ni(<scp>ii</scp>)/bidentate P-ligand/Zn system with ZnI<sub>2</sub> as an additive
Jiangtao Fan, Xin‐Heng Fan, Cai‐Yan Gao, Jinchao Wei, Lian‐Ming Yang
Abstract
A nickel-catalyzed regioselective cyclotrimerization of alkynes provides straightforward access to 1,2,4- or 1,3,5-trisubstituted benzenes. This protocol features the advantages of broad substrate scope and easily controllable regioselectivity.
Topics & Concepts
RegioselectivityChemistryAlkyneCatalysisDenticitySubstrate (aquarium)Ligand (biochemistry)Combinatorial chemistryNickelOrganic chemistryMetalBiochemistryOceanographyGeologyReceptorCatalytic Alkyne ReactionsCatalytic C–H Functionalization MethodsCyclopropane Reaction Mechanisms