A serotonergic axon-cilium synapse drives nuclear signaling to alter chromatin accessibility
Shu‐Hsien Sheu, Srigokul Upadhyayula, Vincent Dupuy, Song Pang, Fei Deng, Jinxia Wan, Deepika Walpita, H. Amalia Pasolli, Justin R. Houser, Silvia Sánchez-Martínez, Sebastián Brauchi, Sambashiva Banala, Melanie Freeman, C. Shan Xu, Tomas Kirchhausen, Harald F. Hess, Luke D. Lavis, Yulong Li, Séverine Chaumont‐Dubel, David E. Clapham
Abstract
-RhoA pathway, which modulates nuclear actin and increases histone acetylation and chromatin accessibility. Ablation of this pathway reduces chromatin accessibility in CA1 pyramidal neurons. As a signaling apparatus with proximity to the nucleus, axo-ciliary synapses short circuit neurotransmission to alter the postsynaptic neuron's epigenetic state.
Topics & Concepts
SerotonergicBiologyCiliumNeuroscienceSynapseAxonCell biologySerotoninReceptorBiochemistryPhotoreceptor and optogenetics researchRetinal Development and DisordersNeuroscience and Neuropharmacology Research