Ru(<scp>ii</scp>)-catalyzed external auxiliary-free primary amide-directed inverse Sonogashira reaction on (hetero)arylamides
Akanksha Singh Baghel, Amit Kumar
Abstract
double C-H bond activation in the presence of bromo-alkynes as coupling partners. The attractive features of the developed strategy lie in the usage of an inexpensive ruthenium(II)-salt, external auxiliary-free directing group and simple reaction conditions, along with a broad substrate scope, high reaction yields and scale-up synthesis.
Topics & Concepts
RutheniumCatalysisSonogashira couplingChemistryCombinatorial chemistryAmideSubstrate (aquarium)Primary (astronomy)Organic chemistryPalladiumPhysicsOceanographyGeologyAstronomyCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsSulfur-Based Synthesis Techniques