Supramolecularly regulated artificial transmembrane signal transduction for 'ON/OFF'-switchable enzyme catalysis
Jinxing Hou, Xiaojia Jiang, Feihu Yang, Liang Wang, Tengfei Yan, Shengda Liu, Jiayun Xu, Chunxi Hou, Quan Luo, Junqiu Liu
Abstract
An artificial signal transduction model with a supramolecular recognition headgroup, a membrane anchoring group, and a pro-enzyme catalysis endgroup was constructed. The transmembrane translocation of the transducer can be reversibly regulated by competitive host-guest complexations as an input signal to control an enzyme reaction inside the lipid vesicles.
Topics & Concepts
Transmembrane proteinChemistrySupramolecular chemistryEnzymeSignal transductionMembraneEnzyme catalysisBiophysicsCatalysisArtificial enzymeVesicleSIGNAL (programming language)BiochemistryReceptorBiologyMoleculeOrganic chemistryComputer scienceProgramming languageMolecular Sensors and Ion DetectionSupramolecular Self-Assembly in MaterialsSupramolecular Chemistry and Complexes