Retinol-binding protein 2 (RBP2) binds monoacylglycerols and modulates gut endocrine signaling and body weight
Seung‐Ah Lee, Kryscilla Jian Zhang Yang, Pierre‐Jacques Brun, Josie A. Silvaroli, Jason J. Yuen, Igor Shmarakov, Hongfeng Jiang, Jun Feranil, Xueting Li, Atreju I. Lackey, Wojciech Krężel, Rudolph L. Leibel, Jenny Libien, Judith Storch, Marcin Golczak, William S. Blaner
Abstract
mice show elevated mucosal levels of 2-MAGs. This is accompanied by significantly elevated blood levels of the gut hormone GIP (glucose-dependent insulinotropic polypeptide). Thus, RBP2, in addition to facilitating dietary retinoid absorption, modulates MAG metabolism and likely signaling, playing a heretofore unknown role in systemic energy balance.
Topics & Concepts
Enteroendocrine cellEndocrine systemRetinol binding proteinBinding proteinEndocrinologyChemistryInternal medicineBiologyBiochemistryRetinolMedicineHormoneVitaminGeneRetinoids in leukemia and cellular processesAntioxidant Activity and Oxidative StressAdipose Tissue and Metabolism