A self-amplifying loop of YAP and SHH drives formation and expansion of heterotopic ossification
Cong Qian, Yuchen Liu, Taifeng Zhou, Yaxing Zhou, Ruoshi Xu, Caiqi Cheng, Hye Soo Chung, Meijun Yan, Hang Zhou, Zhiheng Liao, Bo Gao, Geoffrey A. Bocobo, Taylor A. Covington, Hyeon Ju Song, Peiqiang Su, Paul B. Yu, Yingzi Yang
Abstract
in fibrodysplasia ossificans progressiva (FOP), another genetic HO, and nonhereditary HO mouse models. Genetic or pharmacological inhibition of YAP or SHH abolished HO in POH and FOP and acquired HO mouse models without affecting normal bone homeostasis, providing a previously unrecognized therapeutic rationale to prevent, reduce, and shrink HO.
Topics & Concepts
GNAS complex locusFibrodysplasia ossificans progressivaHeterotopic ossificationCell biologySonic hedgehogBone morphogenetic proteinOsteoblastCancer researchBiologyOssificationHedgehog signaling pathwayEndocrinologyMedicineInternal medicineGeneticsAnatomySignal transductionGeneIn vitroHeterotopic Ossification and Related ConditionsGenetic Syndromes and ImprintingKruppel-like factors research