Label-free imaging and biomarker analysis of exosomes with plasmonic scattering microscopy
Pengfei Zhang, Jiapei Jiang, Xinyu Zhou, Jayeeta Kolay, Rui Wang, Zijian Wan, Shaopeng Wang
Abstract
analyzing binding kinetics between antibody and the surface protein biomarkers on the captured exosomes. Finally, the PSM can be easily constructed on a popular prism-coupled SPR system with commercially available components. Thus, it may provide an economical and powerful tool for clinical exosome analysis and exploration of fundamental issues such as exosome biomarker binding properties.
Topics & Concepts
Surface plasmon resonanceExosomeMicrovesiclesMicroscopyPrismNanotechnologyBiomarkerMaterials sciencePlasmonChemistryNanoparticleOpticsmicroRNAOptoelectronicsPhysicsGeneBiochemistryExtracellular vesicles in diseaseGold and Silver Nanoparticles Synthesis and ApplicationsPlasmonic and Surface Plasmon Research