Circ_0001686 Promotes Prostate Cancer Progression by Up-Regulating SMAD3/TGFBR2 <i>via</i> miR-411-5p
Jiancheng Pan, Zihao Liu, Zhizhao Yang, Enli Liang, Fang Cheng, Dingrong Zhang, Xiaodong Zhou, Yuanjie Niu, Zhongcheng Xin, Yegang Chen, Qiliang Cai
Abstract
PURPOSE: As the mechanism of interaction between circular RNAs (circRNAs) and microRNAs (miRNAs) in regulating the development of prostate cancer (PCa) is not clear, this study focuses on investigating these effects. MATERIALS AND METHODS: findings of miR-411-5p. RESULTS: studies verified that miR-411-5p inhibits PCa progression. CONCLUSIONS: Circ_0001686 can reduce miR-411-5p to increase the expression of SMAD3/TGFBR2, which consequently promotes the proliferation, invasion, and migration of PCa cells.
Topics & Concepts
LNCaPmicroRNAIn vivoWestern blotProstate cancerIn vitroTransfectionChemistryLuciferaseMolecular biologyReporter geneCancer researchCell growthCell cultureBiologyGene expressionCancerGeneBiochemistryGeneticsBiotechnologyCircular RNAs in diseasesMicroRNA in disease regulation