Development and Immunogenicity of a Prototype Multivalent Group B <i>Streptococcus</i> Bioconjugate Vaccine
Jeremy A. Duke, Amy V. Paschall, Lloyd S. Robinson, Cory J. Knoot, Evgeny Vinogradov, Nichollas E. Scott, Mario F. Feldman, Fikri Y. Avci, Christian M. Harding
Abstract
. GBS bioconjugates were purified, analytically characterized, and evaluated for immunogenicity and functional antibody responses. This proof-of-concept study signifies the first step in the development of a next-generation multivalent GBS bioconjugate vaccine, which was validated by the production of conjugates that are able to elicit functional antibodies directed against the GBS capsule.
Topics & Concepts
ImmunogenicityBioconjugationEscherichia coliMicrobiologyConjugate vaccineStreptococcusConjugateBiologyAntibodyChemistryBiochemistryBacteriaImmunologyMathematicsMathematical analysisGeneGeneticsNeonatal and Maternal InfectionsPneumonia and Respiratory InfectionsStreptococcal Infections and Treatments