Detection of the SARS-CoV-2 spike protein in saliva with Shrinky-Dink© electrodes
Julia A. Zakashansky, Amanda Hikari Imamura, Darwin F. Salgado, Heather C. Romero Mercieca, Raphael F. L. Aguas, Angelou M. Lao, Joseph J. Pariser, Netzahualcóyotl Arroyo‐Currás, Michelle Khine
Abstract
Using the children's toy, Shrinky-Dink©, we present an aptamer-based electrochemical (E-AB) assay that recognizes the spike protein of SARS-CoV-2 in saliva for viral infection detection. The low-cost electrodes are implementable at population scale and demonstrate detection down to 1 ag mL-1 of the S1 subunit of the spike protein.
Topics & Concepts
SalivaSpike ProteinSpike (software development)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)2019-20 coronavirus outbreakChromatographyVirologyChemistryBiologyComputer scienceMedicineBiochemistryOutbreakInternal medicineInfectious disease (medical specialty)Software engineeringDiseaseSARS-CoV-2 detection and testingAdvanced biosensing and bioanalysis techniquesBiosensors and Analytical Detection