Future Trends in Asymmetric Organo-Metal Combined Catalysis
Dian‐Feng Chen, Jin Song, Liu‐Zhu Gong
Abstract
Asymmetric organo-metal combined catalysis, which integrates the catalytic functions of chiral organocatalysts and metal complexes, enables the enantioselective formation of challenging chemical bonds and facilitates cascade transformations, often without the need for intermediate purification. Since its inception in 2001, this paradigm has evolved into a versatile strategy for the rapid construction of molecular complexity with a high level of enantioselectivity. In this Outlook, we have highlighted the most recent contributions to this field, showcasing exciting opportunities to overcome current efficiency limits. Looking ahead, we foresee the continued evolution of asymmetric organo-metal catalysis, particularly through the exploration of new catalyst scaffolds, the incorporation of external stimuli, the use of heterogeneous metal catalysts, and the application in macromolecular synthesis.