Mechanoenzymology in the Kinetic Resolution of β-Blockers: Propranolol as a Case Study
Gonzalo Gamboa-Velázquez, Eusebio Juaristi
Abstract
> 300). Moreover, the enantiomerically pure products were used to synthesize both enantiomers of the β-blocker propranolol with high enantiopurity.
Topics & Concepts
Kinetic resolutionBiocatalysisEnantiomerBiotransformationChemistryCandida antarcticaLipasePropranololEnantiomeric excessEnzymeOrganic chemistryCombinatorial chemistryCatalysisEnantioselective synthesisReaction mechanismBiologyEndocrinologyEnzyme Catalysis and ImmobilizationAnalytical Chemistry and ChromatographyEnzyme Structure and Function