Degrading FLT3-ITD protein by proteolysis targeting chimera (PROTAC)
Yong Chen, Xue Yuan, Minghai Tang, Mingsong Shi, Tao Yang, Kongjun Liu, Dexin Deng, Lijuan Chen
Topics & Concepts
ProteolysisChemistryMyeloid leukemiaPhosphorylationChimera (genetics)Protein degradationProteasomeIn vivoFms-Like Tyrosine Kinase 3Cancer researchLeukemiaMutantBiochemistryImmunologyMutationBiologyEnzymeGeneBiotechnologyProtein Degradation and InhibitorsMultiple Myeloma Research and TreatmentsUbiquitin and proteasome pathways