Exosomal miR-21 from tubular cells contributes to renal fibrosis by activating fibroblasts via targeting PTEN in obstructed kidneys
Sheng Zhao, Wei Li, Weimin Yu, Ting Rao, Haoyong Li, Yuan Ruan, Run Yuan, Chenglong Li, Jinzhuo Ning, Siqi Li, Chen Wu, Cheng Fan, Xiangjun Zhou
Abstract
Our findings reveal that exosomal miR-21 from tubular epithelial cells may accelerate the development of renal fibrosis by activating fibroblasts via the miR-21/PTEN/Akt pathway in obstructed kidneys.
Topics & Concepts
MicrovesiclesFibrosisExosomePTENCancer researchFibroblastKidneyMedicinemicroRNAPathologyBiologyCell biologyInternal medicineIn vitroSignal transductionPI3K/AKT/mTOR pathwayBiochemistryGeneExtracellular vesicles in diseaseSystemic Sclerosis and Related DiseasesViral Infections and Vectors