Targeting ANGPTL3 by GalNAc-conjugated siRNA ANGsiR10 lowers blood lipids with long-lasting and potent efficacy in mice and monkeys
Jue Wang, Wen Zheng, Shuquan Zheng, Ye Yuan, Wei Wen, Weiyi Cui, Lifang Xue, Xueting Sun, Haibao Shang, Hongyan Zhang, Rui‐Ping Xiao, Shan Gao, Xiuqin Zhang
Abstract
is effective in treating dyslipidemia and is worth further development.
Topics & Concepts
PharmacologyConjugated systemChemistryMedicineCancer researchCell biologyBiologyOrganic chemistryPolymerLipid metabolism and disordersCancer-related molecular mechanisms researchPeroxisome Proliferator-Activated Receptors