Thin film molecularly imprinted polymer (TF-MIP), a selective and single-use extraction device for high-throughput analysis of biological samples
Fereshteh Shahhoseini, Evan Langille, Ali Azizi, Christina S. Bottaro
Abstract
which are lower than the therapeutic ranges of these drugs. Kinetic and isotherm studies showed the superior performance of MIP sorbent compared to a non-imprinted polymer (NIP) sorbent in extracting TCAs from a bovine serum albumin (BSA) solution. The optimized and validated method for pooled human plasma was utilized for monitoring the concentration of TCAs in three patient samples who had been prescribed TCAs. These selective single-use thin film extraction devices are promising for efficient and fast procedures for analyzing biological samples.
Topics & Concepts
Molecularly imprinted polymerExtraction (chemistry)ThroughputPolymerTricyclicMaterials scienceChromatographyChemistryComputer scienceOrganic chemistryComposite materialCatalysisSelectivityTelecommunicationsWirelessAnalytical chemistry methods developmentAnalytical Chemistry and ChromatographyMass Spectrometry Techniques and Applications