Low-Valent Tungsten Catalysis Enables Site-Selective Isomerization–Hydroboration of Unactivated Alkenes
Tanner C. Jankins, Raúl Martín‐Montero, Phillippa Cooper, Rubén Martı́n, Keary M. Engle
Abstract
A tungsten-catalyzed hydroboration of unactivated alkenes at distal C(sp3)–H bonds aided by native directing groups is described herein. The method is characterized by its simplicity, exquisite regio- and chemoselectivity, and wide substrate scope, offering a complementary site-selectivity pattern to other metal-catalyzed borylation reactions and chain-walking protocols.
Topics & Concepts
ChemistryHydroborationIsomerizationCatalysisTungstenPhotochemistryCombinatorial chemistryOrganic chemistryAsymmetric Hydrogenation and CatalysisOrganometallic Complex Synthesis and CatalysisCatalysis and Oxidation Reactions