Cell type ontologies of the Human Cell Atlas
Osumi-Sutherland, David, Xu, Chuan, Keays, Maria, Levine, Adam P, Kharchenko, Peter V, Regev, Aviv, Lein, Ed, Teichmann, Sarah A
2021UCL Discovery (University College London)112 citations
Abstract
Massive single-cell profiling efforts have accelerated our discovery of the cellular composition of the human body while at the same time raising the need to formalize this new knowledge. Here, we discuss current efforts to harmonize and integrate different sources of annotations of cell types and states into a reference cell ontology. We illustrate with examples how a unified ontology can consolidate and advance our understanding of cell types across scientific communities and biological domains.
Topics & Concepts
OntologyCell typeProfiling (computer programming)Computer scienceCellComputational biologyBiologyBiochemistryProgramming languagePhilosophyEpistemologySingle-cell and spatial transcriptomicsCell Image Analysis TechniquesBioinformatics and Genomic Networks