Laser-Induced Combinatorial Chemotherapeutic, Chemodynamic, and Photothermal Therapy for Hepatocellular Carcinoma Based on Oxaliplatin-Loaded Metal–Organic Frameworks
Run Huang, Weiren Liu, Qinghao Zhang, Guiqi Zhu, Wei‐Feng Qu, Chenyang Tao, Jun Gao, Yuan Fang, Xiutao Fu, Jian Zhou, Ying–Hong Shi, Jia Fan, Zheng Tang
Abstract
High Resolution Image Download MS PowerPoint Slide The activation of nanoparticles (NPs) in the tumor microenvironment exerts synergistic therapeutic effects with chemotherapy against multiple cancers. In this study, an NP system prepared using biocompatible MIL-100 NPs was studied as an effective vehicle to deliver oxaliplatin for hepatocellular carcinoma treatment. The NPs were coated with polydopamine (PDA) and NH 2 -PEGTK-COOH and then loaded with oxaliplatin to create the multi-functional NP [email protected] [email protected] is activated in the tumor microenvironment, causing the generation of cytotoxic reactive oxygen species (ROS) via the Fenton reaction and the release of the loaded oxaliplatin. In addition, under near-infrared (NIR) irradiation, [email protected] can generate hyperthermia at tumor sites. Moreover, owing to the light-induced activation of the [email protected] NPs, higher drug delivery efficiency, more precise targeted activation, and reduced off-target toxicity were observed in in vitro and in vivo experiments. Taken together, owing to its improved drug delivery efficiency and multi-functional activities, including the ability for targeted chemotherapy coupled with photothermal and chemodynamic therapy, [email protected] may serve as a new approach for treating hepatocellular carcinoma.