Synthesis of axially chiral thiourea by NHC-catalyzed desymmetrizative amidation
Yingtao Wu, Xin Guan, Kehan Jiao, Huaqiu Zhao, Mingrui Li, Jiaqiong Sun, Guangfan Zheng, Qian Zhang
Abstract
NHC-catalyzed desymmetrization amidation of biaryl dialdehydes has been developed for NH-free axially chiral thiourea. Sequential kinetic resolution enhances the chirality induction of the desymmetrization strategy, expanding the applicable scope.
Topics & Concepts
ThioureaCatalysisAxial symmetryChemistryCombinatorial chemistryOrganic chemistryMedicinal chemistryPhysicsQuantum mechanicsAxial and Atropisomeric Chirality SynthesisN-Heterocyclic Carbenes in Organic and Inorganic ChemistryAsymmetric Synthesis and Catalysis