Homonuclear Decoupling in <sup>1</sup>H NMR of Solids by Remote Correlation
Pinelopi Moutzouri, Federico M. Paruzzo, Bruno Simões de Almeida, Gabriele Stevanato, Lyndon Emsley
Abstract
Abstract The typical linewidths of 1 H NMR spectra of powdered organic solids at 111 kHz magic‐angle spinning (MAS) are of the order of a few hundred Hz. While this is remarkable in comparison to the tens of kHz observed in spectra of static samples, it is still the key limit to the use of 1 H in solid‐state NMR, especially for complex systems. Here, we demonstrate a novel strategy to further improve the spectral resolution. We show that the anti‐z‐COSY experiment can be used to reduce the residual line broadening of 1 H NMR spectra of powdered organic solids. Results obtained with the anti‐z‐COSY sequence at 100 kHz MAS on thymol, β‐AspAla, and strychnine show an improvement in resolution of up to a factor of two compared to conventional spectra acquired at the same spinning rate.