CCL01, a novel formulation composed of <i>Cuscuta</i> seeds and <i>Lactobacillus paracasei</i> NK112, enhances memory function <i>via</i> nerve growth factor-mediated neurogenesis
In Gyoung Ju, Seong Min Hong, Soo-Won Yun, Eugene Huh, Dong‐Hyun Kim, Sun Yeou Kim, Myung Sook Oh
Abstract
the TrkA/ERK/CREB signaling pathway and neurotrophic factor expression. Moreover, when CCL01 was administered and scopolamine was injected, CCL01 ameliorated memory decline. These results suggest that CCL01 is an effective enhancer of memory function and can be applied to various age groups requiring memory improvement.
Topics & Concepts
NeurogenesisNerve growth factorDoublecortinNeurotrophic factorsHippocampusBrain-derived neurotrophic factorNeuroblastCREBMAPK/ERK pathwayBiologyMedicineSignal transductionEndocrinologyNeuroscienceCell biologyInternal medicineTranscription factorBiochemistryDentate gyrusReceptorGeneMedicinal Plants and NeuroprotectionNeurogenesis and neuroplasticity mechanismsNeuroinflammation and Neurodegeneration Mechanisms