Design, synthesis, and biological evaluation of 3, 5-disubsituted-1H-pyrazolo[3,4-b]pyridines as multiacting inhibitors against microtubule and kinases
Chengqing Ning, Axiao Tao, Jing Xu
Topics & Concepts
KinaseChemistryTubulinMicrotubuleIn vivoCell cycle checkpointCell cycleRational designPharmacologyLead compoundBiochemistryIn vitroCellCell biologyBiologyGeneticsBiotechnologyCancer therapeutics and mechanismsSynthesis and biological activityCancer Mechanisms and Therapy