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PARP1 inhibitors induce pyroptosis via caspase 3-mediated gasdermin E cleavage

Chiho Kim, Xudong Wang, Seoyeon Jang, Yonghao Yu

2023Biochemical and Biophysical Research Communications10 citationsDOIOpen Access PDF

Topics & Concepts

PyroptosisPARP1Cancer researchProgrammed cell deathDNA damageCaspaseBiologyCell biologySynthetic lethalityEffectorPoly ADP ribose polymeraseDNA repairChemistryApoptosisDNAGeneticsPolymerasePARP inhibition in cancer therapyCell death mechanisms and regulationInflammasome and immune disorders
PARP1 inhibitors induce pyroptosis via caspase 3-mediated gasdermin E cleavage | Litcius