Unmasking the Conformational Stability and Inhibitor Binding to SARS-CoV-2 Main Protease Active Site Mutants and Miniprecursor
Andrey Kovalevsky, Leighton Coates, Daniel W. Kneller, Rodolfo Ghirlando, Annie Aniana, Nashaat T. Nashed, John M. Louis
Topics & Concepts
Oxyanion holeChemistryDimerStereochemistryOxyanionActive siteBinding siteAllosteric regulationProtein structureEnzymeBiochemistryCatalysisOrganic chemistryProtein Structure and DynamicsRNA and protein synthesis mechanismsBiochemical and Structural Characterization