The contrasting regulatory effects of valproic acid on ferroptosis and disulfidptosis in hepatocellular carcinoma
Rongrong Liu, Xinyan Li, Jiayi Xu, Liangwen Yan, Kui Hu, Mengjiao Shi, Yinggang Zhang, Yaping Zhao, Yudan Fan, Gang Wang, Ying Guo, Yetong Feng, Pengfei Liu
Abstract
: Overall, our results highlight the significant role of VPA in differentially regulating ferroptosis and disulfidptosis in HCC cells, thereby offering a precise avenue for addressing drug-resistant HCC in clinical practice.
Topics & Concepts
Hepatocellular carcinomaValproic AcidCancer researchCarcinomaInternal medicineMedicineChemistryBiologyNeuroscienceEpilepsyFerroptosis and cancer prognosisRNA modifications and cancerEpigenetics and DNA Methylation