O-GlcNAcylation of SIX1 enhances its stability and promotes Hepatocellular Carcinoma Proliferation
Yi Chu, Mingzuo Jiang, Nan Wu, Bing Xu, Wenjiao Li, Haiming Liu, Song Su, Yanting Shi, Hao Liu, Xiaoliang Gao, Xin Fu, Di Chen, Xiaowei Li, Weijie Wang, Jie Liang, Yongzhan Nie, Daiming Fan
Abstract
We conclude that O-GlcNAcylation of SIX1 enhances its stability and promotes HCC proliferation. Our findings illustrate a novel feedback loop of SIX1 and O-GlcNAcylation and show that O-GlcNAcylation of SIX1 is an important way to coordinate glucose metabolism and tumor progression.
Topics & Concepts
Hepatocellular carcinomaCancer researchCell growthChemistryCell biologyInternal medicineMedicineBiologyBiochemistryGlycosylation and Glycoproteins ResearchGalectins and Cancer BiologyUbiquitin and proteasome pathways