Silencing of long non-coding RNA Sox2ot inhibits oxidative stress and inflammation of vascular smooth muscle cells in abdominal aortic aneurysm via microRNA-145-mediated Egr1 inhibition
Huyu Lin, Bin You, Xiandong Lin, Xiaohu Wang, Dongsheng Zhou, Zhiqun Chen, Yuanxiang Chen, Ren Wang
Abstract
, which was counteracted by lncRNA Sox2ot. Taken together, the present study provides evidence that downregulation of lncRNA Sox2ot suppressed the expression of Egr1 through regulating miR-145, thus inhibiting the development of AAA, highlighting a theoretical basis for AAA treatment.
Topics & Concepts
Gene silencingDownregulation and upregulationVascular smooth musclemicroRNALong non-coding RNAInflammationOxidative stressEGR1Cancer researchBiologyAbdominal aortic aneurysmCell biologyEndocrinologyGeneImmunologyMedicineBiochemistrySmooth muscleAneurysmSurgeryAortic aneurysm repair treatmentsCancer-related molecular mechanisms research