Cisplatin-resistant NSCLC cells induced by hypoxia transmit resistance to sensitive cells through exosomal PKM2
Dongliang Wang, Chaoshuai Zhao, Fei Xu, Aimi Zhang, Mingming Jin, Kunchi Zhang, Liu Liu, Qian Hua, Jian Zhao, Jianjun Liu, Hao Yang, Gang Huang
Abstract
Our findings revealed that hypoxia-induced exosomes transmit cisplatin resistance to sensitive NSCLC cells by delivering PKM2. Exosomal PKM2 may serve as a promising biomarker and therapeutic target for cisplatin resistance in NSCLC.
Topics & Concepts
MicrovesiclesCisplatinPKM2Cancer researchHypoxia (environmental)ExosomeTumor microenvironmentCancer cellBiologyChemistryCell biologymicroRNACancerGlycolysisBiochemistryChemotherapyPyruvate kinaseGeneticsGeneOrganic chemistryEnzymeOxygenTumor cellsExtracellular vesicles in diseaseMicroRNA in disease regulationCancer-related molecular mechanisms research