Development and validation of molnupiravir assessment in bulk powder and pharmaceutical formulation by the RP-HPLC-UV method
Abdelaziz M. Annadi, Noha M. El Zahar, Nour E. A. Abd El‐Sattar, Ekram H. Mohamed, Safwat A. Mahmoud, Mohamed S. M. Attia
Abstract
, respectively. No significant interference was detected in the presence of the common pharmaceutical formulation excipients. The method was validated following the ICH recommendations. All the obtained results were statistically compared with those using reported methods and there were no significant differences. The method developed in this work was successfully employed for the assessment of MOL in bulk powder and pharmaceutical formulation.
Topics & Concepts
ChromatographyCalibration curveDiluentDetection limitPharmaceutical formulationPhosphate buffered salineHigh-performance liquid chromatographyAcetonitrileChemistrySolventDosage formMaterials scienceAnalytical Chemistry (journal)Nuclear chemistryOrganic chemistrySARS-CoV-2 and COVID-19 ResearchAnimal Virus Infections StudiesViral Infections and Immunology Research