Exercise during pregnancy mitigates negative effects of parental obesity on metabolic function in adult mouse offspring
Rhianna C. Laker, Ali Altıntaş, Travis S. Lillard, Mei Zhang, Jessica J. Connelly, Olivia L. Sabik, Suna Önengüt, Stephen S. Rich, Charles R. Farber, Romain Barrès, Zhen Yan
Abstract
Maternal or paternal obesity causes metabolic impairment in adult offspring in mice. Maternal exercise during gestation can completely mitigate metabolic impairment. Maternal obesity, but not paternal obesity, results in hypermethylation of the Pgc-1α promoter at CpG-260, which can be abolished by maternal exercise.
Topics & Concepts
OffspringPregnancyEndocrinologyObesityInternal medicineMedicinePhysiologyBiologyGeneticsBirth, Development, and HealthAdipose Tissue and MetabolismGestational Diabetes Research and Management