Tat-NTS peptide protects neurons against cerebral ischemia-reperfusion injury via ANXA1 SUMOylation in microglia
Huijuan Zhou, Lulu Yan, He‐Zhou Huang, Xing Li, Qian Xia, Lu Zheng, Bin Shao, Qian Gao, Ning Sun, Jing Shi
Abstract
Our study provides evidence for a novel mechanism of Tat-NTS peptide in regulating microglial ANXA1 function and its substantial neuroprotective effect on neurons with ischemic injuries. These findings suggest that Tat-NTS peptides have a high potential for clinical application and may be a promising therapeutic candidate for treating cerebral ischemia.
Topics & Concepts
MicrogliaIschemiaNeuroprotectionMedicineHippocampal formationIn vivoInflammationNeurosciencePathologyCell biologyPharmacologyBiologyImmunologyInternal medicineBiotechnologyS100 Proteins and AnnexinsNeuroinflammation and Neurodegeneration MechanismsImmune Response and Inflammation