Transcriptomic Profiling Reveals Intense Host-Pathogen Dispute Compromising Homeostasis during Acute Rift Valley Fever Virus Infection
Erick Bermúdez-Méndez, Paolo Angelino, Lucien van Keulen, Sandra van de Water, Barry Rockx, Gorben P. Pijlman, Angela Ciuffi, Jeroen Kortekaas, Paul J. Wichgers Schreur
Abstract
may be a determinant of RVFV tissue tropism. This study links the typical pathological phenotype induced by RVFV infection with tissue-specific gene expression profiles, thereby improving our understanding of RVFV pathogenesis.
Topics & Concepts
BiologyRift Valley feverVirologyViremiaPathogenesisTissue tropismVirusViral pathogenesisPathogenOutbreakImmunologyTropismViral replicationViral Infections and VectorsFire effects on ecosystems