Unravelling the genetic architecture of human complex traits through whole genome sequencing
Ozvan Bocher, Cristen J. Willer, Eleftheria Zeggini
Abstract
Whole genome sequencing has enabled new insights into the genetic architecture of complex traits, especially through access to low-frequency and rare variation. This Comment highlights the key contributions from this technology and discusses considerations for its use and future perspectives.
Topics & Concepts
Genetic architectureKey (lock)DNA sequencingGenomeComputational biologyBiologyArchitectureWhole genome sequencingGenomicsEvolutionary biologyData scienceComputer scienceGeneticsQuantitative trait locusGeneGeographyEcologyArchaeologyGenetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and AnimalsMolecular Biology Techniques and Applications