α-naphthoflavone-derived cytochrome P450 (CYP)1B1 degraders specific for sensitizing CYP1B1-mediated drug resistance to prostate cancer DU145: Structure activity relationship
Peng Chen, Shaobing Wang, Chenyang Cao, Wenchong Ye, Meizhu Wang, Cui Zhou, Wen-Ming Chen, Xu Zhang, Keyu Zhang, Wen Zhou
Topics & Concepts
DU145ChemistryCYP1B1Cytochrome P450PharmacologyDrug resistanceBiochemistryStereochemistryProstate cancerCancerBiologyEnzymeGeneticsLNCaPProtein Degradation and InhibitorsMultiple Myeloma Research and TreatmentsUbiquitin and proteasome pathways