CircHGF suppressed cell proliferation and osteogenic differentiation of BMSCs in ONFH via inhibiting miR-25-3p binding to SMAD7
Xiaobo Feng, Qian Xiang, Jie Jia, Tingting Guo, Zhiwei Liao, Shuhua Yang, Xianyi Cai, Xianzhe Liu
Abstract
. Results showed that circHGF suppressed the proliferation and osteogenic differentiation of BMSCs in ONFH by targeting miR-25-3p/SMAD7 axis. Our findings provided a potential diagnostic and therapeutic strategy for ONFH.
Topics & Concepts
Mesenchymal stem cellDownregulation and upregulationCancer researchCell growthCellular differentiationCell biologymicroRNAStem cellCircular RNABone marrowChemistryBiologyImmunologyGeneGeneticsBone and Joint DiseasesCircular RNAs in diseasesCancer-related molecular mechanisms research