Genomic Analysis of Vancomycin-Resistant Staphylococcus aureus Isolates from the 3rd Case Identified in the United States Reveals Chromosomal Integration of the <i>vanA</i> Locus
Wolfgang Haas, Navjot Singh, William Lainhart, Lisa Mingle, Elizabeth Nazarian, Kara Mitchell, Geetha Nattanmai, Donna Kohlerschmidt, Michelle C. Dickinson, Marilyn Kacica, Nellie B. Dumas, Kimberlee A. Musser
Abstract
High-level vancomycin-resistant Staphylococcus aureus (VRSA) began to emerge in the United States in 2002 and has since then been reported worldwide. Our study reports the closed genome sequences of multiple VRSA isolates obtained in 2004 from a single patient in New York State.
Topics & Concepts
PlasmidBiologyTransposable elementStaphylococcus aureusPulsed-field gel electrophoresisLocus (genetics)GeneticsChromosomeMicrobiologyGenomeAntibiotic resistanceSCCmecMultiple drug resistanceMethicillin-resistant Staphylococcus aureusGeneAntibioticsBacteriaGenotypeAntimicrobial Resistance in StaphylococcusBacterial Identification and Susceptibility TestingBacterial biofilms and quorum sensing