Aryl hydrocarbon receptor confers protection against macrophage pyroptosis and intestinal inflammation through regulating polyamine biosynthesis
Yajing Gao, Kwei-Yan Liu, Wenfeng Xiao, Xueru Xie, Qiuyan Liang, Zikun Tu, Lan Yang, Hongmiao Yu, Haiyan Guo, Saihua Huang, Xiao Han, Jinrong Fu, Yufeng Zhou
Abstract
These findings suggest a functional role for the AhR/ODC1/polyamine axis in maintaining intestinal homeostasis, providing potential targets for treatment of inflammatory bowel disease.
Topics & Concepts
Aryl hydrocarbon receptorPyroptosisInflammationChemistryBiologyInflammasomeCell biologyMolecular biologyCancer researchImmunologyBiochemistryTranscription factorGeneImmune Cell Function and InteractionHeme Oxygenase-1 and Carbon MonoxideCannabis and Cannabinoid Research