HDAC1 and 2 regulate endothelial VCAM-1 expression and atherogenesis by suppressing methylation of the <i>GATA6</i> promoter
Chengxiu Hu, Kai Peng, Qianqian Wu, Yiying Wang, Xing Fan, Dai‐Min Zhang, Anthony G. Passerini, Chongxiu Sun
Abstract
promoter methylation. These findings may provide a rationale for HDAC1/2-targeting therapy in atherosclerotic heart disease.
Topics & Concepts
GATA6Cancer researchRomidepsinMolecular biologyDNA methylationBiologyEpigeneticsMethylationChemistryTranscription factorGene expressionHistone deacetylaseHistoneBiochemistryGeneHistone Deacetylase Inhibitors ResearchEpigenetics and DNA MethylationNuclear Receptors and Signaling