Loss of the fragile X syndrome protein FMRP results in misregulation of nonsense-mediated mRNA decay
Tatsuaki Kurosaki, Naoto Imamachi, Christoph Pröschel, Shuhei Mitsutomi, Rina Nagao, Nobuyoshi Akimitsu, Lynne E. Maquat
Topics & Concepts
Nonsense-mediated decayFragile X syndromeBiologyCell biologyTranscriptomeInduced pluripotent stem cellTranslation (biology)Messenger RNAPhenotypeRNA-binding proteinHyperactivationGeneticsEmbryonic stem cellRNAGene expressionGeneRNA splicingGenetics and Neurodevelopmental DisordersCRISPR and Genetic EngineeringPluripotent Stem Cells Research