Muscle-derived Myoglianin regulates Drosophila imaginal disc growth
Ambuj Upadhyay, Aidan J. Peterson, Myung-Jun Kim, Michael B. O’Connor
Abstract
the BMP family member Dpp is produced in a limited set of imaginal disc cells and functions as a classic morphogen to regulate pattern and growth by diffusing throughout imaginal discs. However, the role of TGFβ/Activin-like ligands in disc growth control remains ill-defined. Here, we demonstrate that Myoglianin (Myo), an Activin family member, and a close homolog of mammalian Myostatin (Mstn), is a muscle-derived extrinsic factor that uses canonical dSmad2-mediated signaling to regulate wing size. We propose that Myo is a myokine that helps mediate an allometric relationship between muscles and their associated appendages.
Topics & Concepts
Imaginal discDecapentaplegicMorphogenCell biologyBiologyDrosophila melanogasterMyokineSignal transductionDevelopmental biologyDrosophila (subgenus)AnatomyGeneticsSkeletal muscleGeneDevelopmental Biology and Gene RegulationMuscle Physiology and DisordersTGF-β signaling in diseases