SPARC production by bone marrow-derived cells contributes to myocardial fibrosis in pressure overload
Hannah J. Riley, Ryan R. Kelly, An O. Van Laer, Lily S. Neff, Shaoni Dasgupta, Catalin F. Baicu, Lindsay T. McDonald, Amanda C. LaRue, Michael R. Zile, Amy D. Bradshaw
Abstract
Myocardial fibrosis and the resultant increases in LV and myocardial stiffness represent pivotal consequences of chronic pressure overload (PO). In this study, a murine model of cardiac fibrosis induced by PO was used to demonstrate a critical function of SPARC in bone marrow-derived cells that drives cardiac fibrosis and increases in cardiac macrophages.
Topics & Concepts
Pressure overloadBone marrowInternal medicineCardiologyMyocardial fibrosisMedicineProduction (economics)Information overloadFibrosisHeart failureComputer scienceCardiac hypertrophyWorld Wide WebMacroeconomicsEconomicsBone and Dental Protein StudiesMesenchymal stem cell researchTissue Engineering and Regenerative Medicine