Specific immune modulation of experimental colitis drives enteric alpha-synuclein accumulation and triggers age-related Parkinson-like brain pathology
Stefan Grathwohl, Emmanuel Quansah, Nazia Maroof, Jennifer A. Steiner, Liz Spycher, Fethalla Benmansour, Gonzalo Durán-Pacheco, Juliane Siebourg‐Polster, Krisztina Oroszlan‐Szovik, Helga Remy, Markus Haenggi, Marc Stawiski, Matthias Selhausen, Pierre Mailver, Andreas Wolfert, Thomas Emrich, Zachary Madaj, Arel Su, Martha L. Escobar Galvis, Christoph Mueller, Annika Herrmann, Patrik Brundin, Markus Britschgi
Abstract
: Our data suggest that specific types and severity of intestinal inflammation, mediated by monocyte/macrophage signaling, could play a critical role in the initiation and progression of PD.
Topics & Concepts
Enteric nervous systemSubstantia nigraColitisGenetically modified mouseInflammationTyrosine hydroxylaseAlpha-synucleinMyenteric plexusBiologyInflammatory bowel diseasePathologyImmunostainingTransgeneNeurodegenerationImmunologyParkinson's diseaseMedicineEndocrinologyImmunohistochemistryDiseaseBiochemistryGeneParkinson's Disease Mechanisms and TreatmentsChild Nutrition and Feeding IssuesDysphagia Assessment and Management