Identification of an allosteric site on the E3 ligase adapter cereblon
Vanessa N. Dippon, Zeba Rizvi, Anthony E. Choudhry, Chun-wa Chung, Ibrahim F. Alkuraya, Wenqing Xu, Xavier B. Tao, Anthony J. Jurewicz, Jessica L. Schneck, Wenqian Chen, Nicole M. Curnutt, Farah Kabir, Kwok-Ho Chan, Markus A. Queisser, Caterina Musetti, Han Dai, Gabriel C. Lander, Andrew B. Benowitz, Christina Woo
Topics & Concepts
Allosteric regulationCereblonChemistryUbiquitin ligaseBinding siteComputational biologyPlasma protein bindingLigand (biochemistry)Ubiquitin-Protein LigasesAllosteric enzymeBiophysicsDrug discoveryUbiquitinAdapter (computing)Small moleculeChemical biologyCell biologyBiochemistryReceptorBinding pocketStereochemistryG protein-coupled receptorAminopyridinesSignal transducing adaptor proteinProtein Degradation and InhibitorsHistone Deacetylase Inhibitors ResearchChromatin Remodeling and Cancer