Cascade Michael/aldol/rearrangement between phenacylmalononitriles and maleimides: highly diastereoselective access to functionalized bicyclic cyclopentenes containing a CN-substituted all-carbon quaternary center
Li Gao, Gaihui Li, Xiaokang Li, Guoshun Zhang, Min Zhang, Qingshan Li, Shurong Ban
Abstract
A highly diastereoselective approach towards the synthesis of quaternary center-containing cyclopentenes was developed. The tandem Michael/aldol/rearrangement processes occurred under mild reaction conditions.
Topics & Concepts
ChemistryAldol reactionCascadeQuaternary carbonBicyclic moleculeMichael reactionStereochemistryCombinatorial chemistryOrganic chemistryEnantioselective synthesisCatalysisChromatographyAsymmetric Synthesis and CatalysisCatalytic C–H Functionalization MethodsChemical Synthesis and Analysis