Tobramycin Adaptation Enhances Policing of Social Cheaters in Pseudomonas aeruginosa
Rhea G. Abisado, John H. Kimbrough, Brielle M. Mckee, Vaughn D. Craddock, Nicole E. Smalley, Ajai A. Dandekar, Josephine R. Chandler
Abstract
that suppresses cheaters independent of tobramycin through pleiotropic regulation of a policing toxin, pyocyanin. This work supports the idea that adaptation to antibiotics can have unexpected effects on the evolution of quorum sensing and has implications for understanding how cooperation evolves in dynamic bacterial communities.
Topics & Concepts
Quorum sensingPseudomonas aeruginosaCheatingTobramycinOpportunistic pathogenAdaptation (eye)MicrobiologyBiologyPseudomonasMutantBacteriaBiofilmGeneGeneticsEcologyNeuroscienceBacterial biofilms and quorum sensingBacterial Genetics and BiotechnologyBiochemical and Structural Characterization