Iron-Catalyzed Csp<sup>2</sup>–Csp<sup>3</sup> Cross-Coupling via Double Decarboxylation: One Step Synthesis of Remote Polar Alkenes
Ni Xiong, Chengxiang Zhou, Shiyi Li, Sichang Wang, Congyu Ke, Zhouting Rong, Yang Li, Rong Zeng
Abstract
Herein, we report an efficient photoinduced iron-catalyzed strategy for cross-couplings of alkyl carboxylic and acrylic acids, which provides a powerful tool for the synthesis of a variety of alkenes with polar functional groups. This novel synthetic methodology can also be applied to the preparation of ketones by using α-keto acids. Mechanistic experiments revealed preliminary mechanistic details. Diverse functionalization could be achieved, which may help streamline the synthesis of complex analogues for drug discovery.
Topics & Concepts
ChemistryDecarboxylationCombinatorial chemistryCatalysisPolarAlkylSurface modificationOrganic chemistryAstronomyPhysicsPhysical chemistryCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsSulfur-Based Synthesis Techniques