Ginsenoside compound K alleviates <scp>d</scp>-galactose-induced mild cognitive impairment by modulating gut microbiota-mediated short-chain fatty acid metabolism
Xiaojun Yan, Xue Bai, Rongzhan Fu, Zhiguang Duan, Wen Zeng, Chenhui Zhu
Abstract
, and modulated the levels of short-chain fatty acids (SCFAs), particularly increasing propionate, thereby alleviating gut microbiota dysbiosis caused by MCI. Germ-free experiments confirmed that gut microbiota is a key factor for ginsenoside CK in relieving MCI. Further investigation revealed that CK regulated the TLR4-MyD88-NF-κB signaling pathway through modulation of gut microbiota-mediated propionate metabolism, significantly reducing systemic inflammation and alleviating MCI. Our findings provide a new theoretical basis for using CK as a potential means of modulating the gut microbiota for the treatment of MCI.
Topics & Concepts
Gut floraChemistryPropionateAkkermansiaGalactoseMetabolismBiochemistryPharmacologyBiologyFermentationLactobacillusGut microbiota and healthTryptophan and brain disordersGinseng Biological Effects and Applications