A carbon dot-based nanoscale covalent organic framework as a new emitter combined with a CRISPR/Cas12a-mediated electrochemiluminescence biosensor for ultrasensitive detection of bisphenol A
Rongxian Ma, Jiaxuan Jiang, Yanfei Ya, Yu Lin, Yuyi Zhou, Yeyu Wu, Xuecai Tan, Ke‐Jing Huang, Fangkai Du, Jing‐Juan Xu
Abstract
with a low detection limit of 2.21 fM (S/N = 3) under the optimized conditions. The biosensor demonstrated that CD-COF can be used as an efficient ECL emitter, thus expanding the application field of COFs. In addition, the good stability and specificity of the biosensor enabled the rapid detection of BPA, which will provide valuable insights into promising ultrasensitive ECL biosensors.
Topics & Concepts
ElectrochemiluminescenceBiosensorNanotechnologyCovalent bondMaterials scienceCarbon fibersBisphenol ANanoscopic scaleChemistryDetection limitChromatographyOrganic chemistryComposite numberEpoxyComposite materialAdvanced biosensing and bioanalysis techniquesCarbon and Quantum Dots ApplicationsConducting polymers and applications